http://source.winehq.org/git/wine.git/commit/c63e3261f37e8116e59c70b9bed20aa... Since that commit Rx 480 supposed to be recognized, but I am using closed source drivers, because the audio patches arent in upstream yet. I found a real problem from SC2 appdatabase and I could confirm it myself. When you start SC2 and go to options it limits your GPU graphics options. With the attached patch here the options are not limited anymore.