http://bugs.winehq.org/show_bug.cgi?id=46568
--- Comment #10 from Nikolay Sivov bunglehead@gmail.com --- (In reply to Pacho Ramos from comment #9)
I indirectly hit this bug while trying to run GraphPad Prism with wine: https://www.graphpad.com/support/faq/will-you-port-prism-or-instat-to-linux- does-prism-work-with-the-windows-emulator-wine/
I couldn't save project files due to "missing" IE6 for XML support. I solved it by switching to wine-staging, that solves this bug.
This page talks about wine 1.x releases, which is very old. If you are able to test, please try this application with current Wine, without installing msxml6. And then report any issues with XML handling as a new wine bug. It's a better path forward than using a redist.