Perhaps the program Zynamics BinNavi is useful to analyze the win32 applications, etc:
Zynamics BinNavi is the primary binary code reverse engineering tool based on graph visualization

Description

BinNavi is a binary code reverse engineering tool that was built to assist vulnerability researchers who look for vulnerabilities in disassembled code.

With BinNavi you can analyze disassembled x86, ARM, PowerPC, and MIPS code using the powerful built-in static code analysis techniques. In cases where static code analysis is not enough, you can use the built-in debuggers to get a live view on the program you are analyzing.

Use Cases

Do control flow based code analysis of disassembled x86, ARM, MIPS, and PowerPC code
Cut down on complexity by removing unimportant code from functions
Use powerful remote debuggers to debug programs on different operating systems
Use Differential Debugging to quickly locate relevant code
Create and assign user-defined tags to mark important functions and basic blocks
Use advanced code analysis algorithms to keep track of data and code
Manage all your reverse engineering projects in one central database
Write scripts and plugins to extend BinNavi to meet your specific goals
Rename and annotate variables and functions to make them self-explanatory
Use the REIL meta-language to write platform-independent program analysis code

To learn more about the features and use cases of BinNavi please take a look at the BinNavi manual.

I think that it is easier to see how they are running operations on files connected with the BinNavi program. Since is a transparent, simpler and interesting debugger.

link http://www.zynamics.com/binnavi.html

Forgive this text is translated by translatica.pl.