I've tested some games (wine 1.7.1 64-bit for Guild Wars 2 and SCII, 32-bit for Skyrim, no wined3d/d3d patch except the patchset for CSMT).

I have a GTX660 (slightly overclocked, +10 Mhz or so) with the 325.15 Nvidia blob and an Intel i5 2500K (overclocked to 4.2 Ghz).

#Guild Wars 2(in the Lion's Arch with ~75-100 players, always from the same spot):

Quality Options:
     -Fullscreen Mode
     -1600x1200
     -Animation: High
     -Anti-aliasing: FXAA
     -Environment: High
     -LOD: Excellent
     -Textures: High
     -Reflections: Land and Sky(causes high frame rate drops when moving the camera)
     -Render Sampling: Supersampling
     -Shadows: High
     -Shaders: High
     -Post-processing: High(absolutely doesn't influence frame rate)
     -No High Res Character Textures
     -Character model limit/Character model quality: Medium
     -VSyng: Off
     -Optimal Texture Filtering: Off(no real effect except reducing the FPS)

Without -dx9single(it should use more than one core and DX10 then):
     -With __GL_THREADED_OPTIMIZATIONS: 30-45 FPS in the login screen, 8-10 FPS when not moving the camera, 3-5 FPS when moving it.
     -Without __GL_THREADED_OPTIMIZATIONS: 60 FPS in the login screen, 18-20 FPS when not moving the camera, 5-10 FPS when moving it.

With -dx9single(the game is far more quicker to load with it):
     -With __GL_THREADED_OPTIMIZATIONS: >60 FPS in the login screen, 23-24 FPS when not moving the camera, 5-20 FPS when moving it.
     -Without __GL_THREADED_OPTIMIZATIONS: >60 FPS in the login screen, 23-24 FPS when not moving the camera, 20 FPS when moving it.

Conclusion: -dx9single is GOOD and __GL_THREADED_OPTIMIZATIONS is BAD.

#Starcraft II

Quality Options: Ultra(default mode, also for the textures).
The game claims 50-70 FPS, but it seems to lag when moving the camera and the output is only trash (I need to change a graphical setting to be able to see anything).
With __GL_THREADED_OPTIMIZATIONS, it's even more laggy and the FPS drop below 40.

#Skyrim

Quality Options: Very High.
I can't see the FPS of the game, but it was running smoothly and is still running smoothly with the patchset.
I didn't tried with __GL_THREADED_OPTIMIZATIONS(well, I tried long ago, and that was horribly slow).

I also want to say that wine is spamming "Waiting for the cs" in the console (I assume it's nothing really important as the project seems to be WIP, why asking for tester otherwise?) and wgl errors (err:wgl:wglFlush wglFlush).

Cordially.

P.S. : Sorry for my English, I am still learning it.
--
Pierre Franco
nob.dir.info@gmail.com