http://source.winehq.org/git/wine.git/commit/c63e3261f37e8116e59c70b9bed20aa90c39e8a1

Since that commit Rx 480 supposed to be recognized, but I am using closed source drivers, because the audio patches arent in upstream yet. I found a real problem from SC2 appdatabase and I could confirm it myself. When you start SC2 and go to options it limits your GPU graphics options and complains not enough memory. With the attached patch here the options are not limited anymore.