Hi!
Have tried for a while to get Mass Effect 2 working through Wine and though it's very playable for me it has a large drawback, I have to disable all movie playbacks with the -nomoviestartup argument. If I don't, the game freezes up and I can hear the sound stuck in a loop - it does not unfreeze itself.
By looking through AppDB it seems that there are a large group of people that doesn't have this problem. I assume it's either related to my processor (AMD A10-6700) or GPU (HD5770, Catalyst driver)? I have tried to several Wine versions but it didn't help.