I think it would be very interesting to see how a meson wine build would perform and affect the workflow. One benefit I don't see mentioned is the ability to generate compile_commands.json, which allows IDEs to perform intelli-sense on the codebase. Right now I use bear (
https://github.com/rizsotto/Bear), but this requires you to regenerate the compile_commands.json whenever you add a file to wine.
If you can get past the technical hurdles mentioned above and more, I think many people would be interested in having it as an option alongside autotools.