https://bugs.winehq.org/show_bug.cgi?id=32913
--- Comment #30 from wentam42@gmail.com ---
Upon rare occasion when I switch away and give the window focus again, the mouse will be completely smooth but the mouse buttons won't work in game. This situation is very rare however.
Turns out this situation is when my mouse cursor is outside of the fullscreen window, with the fullscreen window still the window in focus.