https://bugs.winehq.org/show_bug.cgi?id=46257
--- Comment #4 from Stuart Axon stu.axon@gmail.com --- I'm having a go at something in C++, I'll try and come back with the detailed python install instructions and a single file you can run, it got complicated by a few bugs.
The short version is, installing python3.5 or 3.6. then using pip to install pywin32.
(I would recommend python2.7, but there seemed to be a bug in pywin32 that prevented this).
I had to use wine-staging as there was a bug stopping install of 3.5 or 3.6.
Once it's installed use pip to install pywin32.
...
Except this may not work, I managed to make a patch to pip that made this able to work in Wine.
I'll do it again and document it here, but if you manage to get any version of python installed under wine with pywin32, let me know - alternately just wait for further info :)