https://bugs.winehq.org/show_bug.cgi?id=51420
--- Comment #28 from mitchell4136@gmail.com --- WineHQ FAQ even has a page on that infamous message:
https://wiki.winehq.org/FAQ#Broken_NVIDIA_RandR_detected.2C_falling_back_to_...
I've tried applying their fixes in xorg.conf to no avail. Of course running wine on Wayland (bypassing xorg all together) makes the problem go away.