https://bugs.winehq.org/show_bug.cgi?id=49805
--- Comment #21 from ldhacker@live.com --- Sorry if I am spamming everyone's email boxes.
I was looking through the program files of Pyxel Edit and found that it uses Adobe Air 1.0. (I assume this because the directory path is /.wine/drive_c/Program Files (x86)/PyxelEdit/Adobe AIR/Versions/1.0/)
Apparently, Adobe Air is now at version 32, and Linux support (I know this doesn't necessarily matter for this, since we're running in wine) was ended after version 2.6.