https://bugs.winehq.org/show_bug.cgi?id=48965
--- Comment #2 from Marko Friedemann mfr@bmx-chemnitz.de --- I have a number of skills assigned to key combinations ALT+(1..6).
Those do not work, and it's not that ALT would get ignored, there is no reaction at all (ie, it does not just send 1..6).
I didn't know what specifically I could try to test stuff, so I started a notepad.exe with the same launcher script (same WINEPREFIX, same wine binary, same settings, ...) and there I was able to press ALT+(menu hotkeys, but letter characters). But that is not a fullscreen application with DX, so I don't know what else might differ.
I then went to search, found the forum entry, grepped in the git log a bit and found that commit which seemed reasonable to be reverted for a try. So I did, and without those changes, the key combinations work as before.
HTH, M.