https://bugs.winehq.org/show_bug.cgi?id=40165
--- Comment #3 from Ken Thomases ken@codeweavers.com --- There's no notion of "v-sync being turned-on system wide on […] macOS". The Mac driver, however, defaults to v-sync being enabled for windows. (I expect the X11 driver does, too, but haven't checked recently.) The application would have to turn it off if it wants it off. A +wgl log should show if it's doing that.
There's a registry setting to force v-sync off, but not one to force it on.