https://bugs.winehq.org/show_bug.cgi?id=45582
--- Comment #3 from Andrew Eikum aeikum@codeweavers.com --- Can you try reverting back to the default PulseAudio configuration and see if that helps? If so, you can try turning your options back on to see what triggers the failure.
In particular, I'm suspicious of these lines in daemon.conf:
default-fragments = 2 default-fragment-size-msec = 125
Does removing them help?