https://bugs.winehq.org/show_bug.cgi?id=44434
--- Comment #7 from Gcenx gcenx83@gmail.com --- The message is a none issue and can be ignored, this only affects 32Bit binaries not 64Bit binaries.
When wine is installed directly into /usr/local you won’t see this message (seems like there’s a whitelist of some kind). Unfortunately as the vast majority of macOS users use brew as there package manager that location can not be used.
Anyone using macports-wine (my macports overlay) and installs one of the provided wine-* packages won’t see this issue.