http://bugs.winehq.org/show_bug.cgi?id=23807
--- Comment #8 from Scott Ritchie scott@open-vote.org 2010-11-16 06:49:52 CST --- Retested today with the latest NS2 update and Wine 1.3.7, and it behaves differently. Rather than blank, there is some copyright text visible on the screen at the bottom. A new trace is attached.
The game helpfully prints a "Natural Selection 2 Started" to the console so you can pass the steam parts of the trace.
In addition to the PDF above, this link gives some more detail on the DF16/DF24 formats: http://aras-p.info/texts/D3D9GPUHacks.html -- it also mentions how this might affect other cards. I'll attach another trace run as well.