https://bugs.winehq.org/show_bug.cgi?id=45626
--- Comment #2 from Ken Thomases ken@codeweavers.com --- (In reply to Rastafabi from comment #1)
If this does help anybody:
The status of the eGPU setting can be read here:
defaults read -app <app path> GPUSelectionPolicy
The command does "fail", if the setting hasn't been altered previously, so it's safe to assume, that "prefer eGPU" hasn't been selected. Enabling it does not affect the system if there is no eGPU present.
Have you tried the following command to see if it helps?
defaults write org.winehq.wine GPUSelectionPolicy -string preferRemovable
To revert to the default, you would use:
defaults delete org.winehq.wine GPUSelectionPolicy