http://bugs.winehq.org/show_bug.cgi?id=32050
--- Comment #11 from Xavier Vachon xvachon@gmail.com 2013-05-12 01:19:45 CDT --- Some extended testing today. I found that if antialiasing and high-res textures are disabled, I can run the game for a long time (played for an hour straight today, no problem). If AA is enabled, regardless of the value, it runs at some point into GL_OUT_OF_MEMORY errors (15-20 minutes of gameplay with AA8x). Used only d3dx11_43 as an override, no registry keys or other winetricks stuff required.
I also run into a strange AA bug where in Windows 7, DA2 does not allow AA more than 8x, but in Wine, DA2 allows AA to go to 16x. Would be good if somebody could confirm this, but this could maybe explain all the troubles I had to make the game work.