https://bugs.winehq.org/show_bug.cgi?id=53529
--- Comment #6 from formigoni ruanformigoni@gmail.com --- Hi, although that is the case, the issues seems to be fixed. The "No such file or directory" is gone and wine opens. I conducted some testing here: https://github.com/mmtrt/WINE_AppImage/issues/15, an appimage built on ubuntu jammy works on focal and bionic, without the need to install libc6-i386.