https://bugs.winehq.org/show_bug.cgi?id=39793
--- Comment #2 from Alex Henrie alexhenrie24@gmail.com --- There is a workaround for this bug: Add 8250.nr_uarts=<n> to the Linux kernel command line, where <n> is the number of serial ports physically present on your motherboard. This will make Linux create the exact right number of serial port device files.
See http://tldp.org/HOWTO/Serial-HOWTO-15.html#ss15.3 for details.