http://bugs.winehq.org/show_bug.cgi?id=33479
--- Comment #20 from Hans Nieser hans@nieser.nl --- This also affects EVE Online, but in my case *only* if I also have Synergy running (with EVE running on the same machine as the Synergy server, i.e. it's not being controlled remotely). I bisected this to the exact same commit mentioned above and reverting it fixes the issue and lets met play EVE while running Synergy at the same time again.
See bug 35357 for the dup I filed