https://bugs.winehq.org/show_bug.cgi?id=39744
--- Comment #6 from Andrew Eikum aeikum@codeweavers.com --- (In reply to jre.winesim from comment #5)
In case you are using the debian.org packages, there we export PULSE_LATENCY_MSEC=60 per default.
That does seem to be relevant. Did you do this to help the winealsa driver along? If so, it should no longer be needed with winepulse.