http://bugs.winehq.org/show_bug.cgi?id=11811
--- Comment #30 from Hans Leidekker hans@it.vu.nl 2008-03-19 09:10:23 --- It's a volatile key so you have to keep some app running in the background:
$ notepad & $ regedit ~/Documents/Serialcomm_02.reg $ ln -s /dev/ttyS0 ~/.wine/dosdevices/com4 $ wine CE.exe
Where com4 should match what's in the registry file for your Keyspan device and /dev/ttyS0 should be the com port that your GPS device is attached to.