http://bugs.winehq.org/show_bug.cgi?id=12453
--- Comment #30 from Paul "TBBle" Hampson Paul.Hampson@Pobox.com 2009-05-13 05:03:41 --- Looking at Left4Dead's activity, the main culprit for 'Downloading rgb texture to reload it as srgb' appears to be a texture that matches the window size, reloaded every frame, and with WINED3DUSAGE_RENDERTARGET set.
This suggests to my limited understanding that they're rendering the whole scene out in RGB to a texture, and then redrawing it to the screen in SRGB, which is why this bug has such a large effect on framerate.