https://bugs.winehq.org/show_bug.cgi?id=45260
--- Comment #10 from Anthony Jagers noonetinone@gmail.com --- The problem reported by André & Adam has happened to me again with Far Cry 4. No audio in game except cut scenes. I tried to retrace my steps over the last few months. I installed xact. I overrode my dlls. I tried different wine versions. I even tried these new builds of FAudio.
The only thing that worked was manually copying my xaudio2.*.dlls(or the entire install from xact) from my copy of Windows 10 directly into SysWOW64 & System32 folders. That got audio working again. I think installing some new steam games borked my prefix. It looks like winetricks installs an incompatible version. Using dxsetup.exe from Microsoft quit saying new versions were already installed. So, a manual copy was my only option.
I copied these x3daudio*, xactengine*, xapofx* xaudio*.