https://bugs.winehq.org/show_bug.cgi?id=56112
--- Comment #2 from Cedric cedric.dewijs@eclipso.eu --- Avoiding the question of opt-in or opt-out, maybe it's a good first step to print a warning if a user starts a program with the full path like this:
wine ~/path/to/appname.exe
"Starting programs with their full path is unsupported. If the program fails, first cd to ~/path/to and then run wine appname.exe"