https://bugs.winehq.org/show_bug.cgi?id=51561
--- Comment #4 from C. Leu kle@bluewin.ch --- And now follows a short December update.
The situation here has changed somewhat in Wine 7.0-rc2. The described lag (when a line is drawn in Paint.NET 3.5.11) is somehow smaller then in previous versions of Wine.
It is still present, especially when compared with the native gdiplus.dll were the functionality is smooth. However, the delay when a line is draw is definitely shorter then previously.
The crash of Paint.NET 3.5.11 in conjunction with the native gdiplus.dll is as well present and reproducible. This doesn't occur with the built-in gdiplus.dll.
Finally I wish all those reading happy holidays and a good switch into the new year 2022! :-)