https://bugs.winehq.org/show_bug.cgi?id=53910
--- Comment #25 from Rafał Mużyło galtgendo@o2.pl --- Also a note (not sure if related or not): lately (measured in months) I've noticed something odd in random Unity games - upon being closed, even if they were running windowed, they remove the second monitor from xrandr list, that is x11 desktop (not just wine) goes from two active monitors to one.
Not sure when that began, as I've been ignoring it for quite awhile (happens only with Unity (AFAICT) and only on shutdown).