https://bugs.winehq.org/show_bug.cgi?id=40479
--- Comment #46 from Adam Bolte abolte@systemsaviour.com --- If I run Enemy Front (a first person shooter) under Wine 2.0 in full screen mode and use the keyboard to go through the menus and start the game, the mouse won't respond to movement until it is clicked. Once clicked, the mouse works fine for the rest of the game. I agree, it seemed focus-related.
Almost forgot to file a bug for that behaviour until I read that page. Will try to remember do so when I'm in front of my computer which has the game installed.