http://bugs.winehq.org/show_bug.cgi?id=19514
--- Comment #4 from Maciej Pilichowski bluedzins@wp.pl 2009-07-30 11:02:55 --- Austin, E: is drive next to C:
~/.wine/drive_c/ ~/.wine/drive_e/
the second directory is for E:, first one for C: -- it is on linux partition, configured using winecfg. I use E: for installing all apps, "just in case", and I don't touch C: at all.