http://bugs.winehq.org/show_bug.cgi?id=11029
--- Comment #4 from Austin English austinenglish@gmail.com 2008-01-21 13:33:27 --- (In reply to comment #3)
I can confirm that wine-0.9.53 still has this issue, using a already played install autoloads a game and mouse works fine except the fact that it don't register the clicks, but you can do spell gestures, making new waypoints, etc..
But is no playable as you need to click in order to do almost everything.
Can you try with a clean .wine directory? Can you try if a native dinput8.dll helps this? Can you try in a virtual desktop?