https://bugs.winehq.org/show_bug.cgi?id=39477
--- Comment #14 from Andrew Eikum aeikum@codeweavers.com --- Yeah. 32-bit processes like STO are limited to about 4 GB of address space. Wine takes a lot, the game takes a lot, and then pulseaudio wants to allocate a contiguous 64 MB chunk. It's not too surprising that that fails in some modern video games.
If the game has a 64-bit version, you could try that in a 64-bit build of Wine, which would let you use all 32 GB of RAM. But probably just changing the PA settings will fix it.