https://bugs.winehq.org/show_bug.cgi?id=33362
--- Comment #23 from Nicholas O'Connor nrfoconnor+wine@gmail.com --- Everyone turn your graphics settings down, you'll be able to play longer without hitting the bug. You should also report whether or not the bug hits you at all after turning them down and any oddities in your wine configuration.
This bug is also being discussed on wine-staging's bugzilla (https://bugs.wine-staging.com/show_bug.cgi?id=335, affected games in this instance are Skyrim and Fallout NV), current working theory is either a memory leak or functions like IDirect3DDevice9::GetAvailableTextureMem being emulated incorrectly (starting at 0, which is incorrect since your window manager is also taking some graphics memory)