http://bugs.winehq.org/show_bug.cgi?id=31936
--- Comment #7 from Austin English austinenglish@gmail.com 2013-04-22 19:34:07 CDT --- (In reply to comment #5)
It shouldn't changes anything, because Wine works as administer (there isn't user accounts, I think)
You're then giving wine and the application full access to your system.
It can also lead to files getting owned by root instead of your user, causing weird issues.