http://bugs.winehq.org/show_bug.cgi?id=33261
--- Comment #1 from David cymerio@gmail.com 2013-03-23 12:58:37 CDT --- I've done some more experiments and I think I've found a workaround.
The workaround is to set: LC_ALL=es_ES.ISO-8859-1 or LC_ALL=es_ES.ISO-8859-15 before executing Wine.
With this the pause key works, and the in-game text editor works OK too (there is a text editor in the game to edit Sims biographies, etc). Tested these symbols among many others in the text editor: ¡¿çñ€ó.
The idea came from Wine bug #30984 which may be related.
I tested also the command "setxkbmap us" and while it fixed the pause key issue (`) it caused other problems, like the in-game text editor working with US layout.