http://bugs.winehq.org/show_bug.cgi?id=27779
--- Comment #60 from Daniel Neugebauer dneuge-bugzilla@energiequant.de 2011-08-15 08:03:13 CDT --- Maybe this is helpful for finding the bug in case it has not yet been located: In Civilization V system and game cursors switch rapidly on movement. The cursor to remain on screen is the system cursor but as long as the cursor is being moved it flickers with the game cursor which seems to completely _replace_ the system cursor (since the game cursor's angle is more pointed, it's visible that there is no system cursor beneath it for a moment).
Civilization V has a demo which could be used to debug wine.
Gentoo 64 Bit, wine 1.3.26, KDE 4.6.2, X.org 1.9.5, compositing turned temporarily off before launching Steam/Civ V