http://bugs.winehq.org/show_bug.cgi?id=11382
--- Comment #1 from Lei Zhang thestig@google.com 2008-01-28 19:39:09 --- What distro / video card / video card driver?
Can you attach the console output?
Unless you're running Wine as root (you shouldn't) Wine cannot possibly lock up your machine. It's most likely caused by your graphics driver.