https://bugs.winehq.org/show_bug.cgi?id=51697
--- Comment #13 from Alexey Kuznetsov axet@me.com --- Another possibility: since those lags not related to file operations (I ran +file) and lags persist during PHOTO MODE (when no physics and quests calulated) and during in-game video it could be Far Cry 5 EasyAntiCheat service activity.
For example this EAC trying to scan binary for injected libraries and doing it using not optimized / slow wine methods. But I also tried to disable EAC using hexedit instructions from PCGaming web site but no luck - lags are here. Who know it maybe still trying to scan.