http://bugs.winehq.org/show_bug.cgi?id=58092
--- Comment #3 from Alexandre Julliard julliard@winehq.org --- ARM64EC is supported, but it's not trivial to build.
Basically you need to build with the custom llvm from https://github.com/bylaws/llvm-mingw, and build Wine with --enable-archs=aarch64,arm64ec. Then you need to build the FEX emulator as ARM64EC, and copy the resulting dll into the prefix as xtajit64.dll.
Hopefully the process will be made easier in the future...