https://bugs.winehq.org/show_bug.cgi?id=51697
--- Comment #12 from Alexey Kuznetsov axet@me.com --- My guess is - some wine methods are not optimized. When game calls a lot of those methods in background it slows the game.
For example: the game Path of Exile works bad with winehq and with a lot of monsters drop FPS to 0, game stuttering a lot. But using lutris wine I do not have this issue and play game no problems even with a lot of monsters on screen lutris do not drop FPS. I guess some intense IO operations were optimized under lutris wine.
I tried lutris wine with Far Cry 5 but no success, same lags.