https://bugs.winehq.org/show_bug.cgi?id=52763
--- Comment #4 from RĂ©mi Bernon rbernon@codeweavers.com --- I would expect the regression to be coming from the limitation of the number of handles, when they were previously dynamically allocated and virtually unlimited, and I'm quite surprised that reducing the number of handles fixes anything.
Native uses 64k handles, though there's maybe a way to increase that I haven't found it.