https://bugs.winehq.org/show_bug.cgi?id=47342
--- Comment #3 from Sophira wine-bugs@theblob.org --- It isn't mentioned in that thread because the current recommended method of playing the game involves using the IsTransgaming patch mentioned in the thread in order to force the launcher to use its built-in Chromium implementation instead of WINE's MSHTML implementation, which doesn't work currently. I didn't intend it to mean that this bug isn't worth leaving open (because it's clearly a problem with MSHTML) but rather to point you in a direction where the game is playable.
I posted that thread. I didn't encounter the -2146697208 error as I'm not using an unpatched Wine (and at the time of the thread being posted, the 404 error wasn't fixed in Wine). Obviously, it's a bug and this should remain open; I just wanted to help you on your way to being able to play the game.