http://bugs.winehq.org/show_bug.cgi?id=17619
--- Comment #4 from Forest Hale lordhavoc@ghdigital.com 2009-03-08 05:16:24 --- Steam flat out refuses to install on any drive that is not DRIVE_FIXED, so all games purchased on Steam are unusable.
Fairly serious for a certain class of people (those using NFS /home and owning games on Steam).
I worked on a patch for making the winecfg settings override NtQueryVolumeInformationFile but found no way to make it not universally override it - it returns DRIVE_FIXED for drives with no winecfg setting, which means NtQueryVolumeInformationFile would be overridden in all cases and that doesn't seem to be the intention.
I only solved this problem in the simplest way possible for all standard wine installs.