https://bugs.winehq.org/show_bug.cgi?id=46412
--- Comment #6 from Jacob Hrbek werifGX@gmail.com --- (In reply to Zack from comment #3)
Not a dup of 45327. That issue refers to the anti-cheating system in which LoL crashes with Wine when apps like Chrome are open. This is a different issue. Read the traceback.txt . I have wine version 3.21. If I need Wine staging, let me know.
Please provide a screenshot (ideally video) of the error message.
Note that https://youtu.be/fTlbIcwaHPc?t=91 (random video from yt) is anti-cheat message from League of Legends, log that you've provided seems to be grabbed from it.