https://bugs.winehq.org/show_bug.cgi?id=46976
--- Comment #14 from Taha t729587@nwytg.net --- https://pastebin.com/raw/BBZm7mw2
Isolating this issue seems like a major pain. I would personally try a different computer first or maybe dual boot (with different configurations like a different distro or DE) and use a different mouse.