https://bugs.winehq.org/show_bug.cgi?id=50570
--- Comment #1 from Henri Verbeet hverbeet@gmail.com --- (In reply to jkfloris from comment #0)
From the README:
Basic requirements: You need to have the X11 development include files installed (called xlib6g-dev in Debian and XFree86-devel in Red Hat).
The xlib6g-dev package no longer exists in Debian. I think Wine needs the libx11-xcb-dev package.
Wine specifically needs libX11.so (among others). In current Debian (buster) that's in libx11-dev. There's also the xorg-dev metapackage which pulls in libx11-dev, as well as several other Xorg development packages; in some regards the xorg-dev package may be a better choice than the libx11-dev package for the average user.