https://bugs.winehq.org/show_bug.cgi?id=56001
--- Comment #2 from Shmerl shtetldik@gmail.com --- I'll provide logs shortly, but a bit of a clarification on what's going on.
If I simply start the game normally and stay in it - shortcuts continue working, and it coincides with KDE's desktop cursor not being hidden.
When I Alt+Tab out of the game and back (which hides KDE cursor), that's when keys for cyberengine tweaks stop working.