https://bugs.winehq.org/show_bug.cgi?id=47359
--- Comment #14 from Olivier F. R. Dierick o.dierick@piezo-forte.be --- Well it might not be so obvious. Installing the DOS application with DOSBox and running it with Wine is unsupported because Wine doesn't know what the DOSBox configuration was when the DOS application was installed and can't reproduce it.
Installing from Wine and running from Wine should be consistent and use the same wine-generated DOSBox configuration.