https://bugs.winehq.org/show_bug.cgi?id=33759
--- Comment #9 from Forest winehq@tibit.com ---
It's presumably the gamma ramp that's being changed and not changed back (by the X11 driver, possibly on behalf of wined3d), not actually the "color profile" as such.
My nvidia-settings control panel shows the color correction curves for red, green, and blue, along with a gamma setting of 1.0. When the problem occurs, those curves get flattened into a single straight line, and gamma remains the same. I think that means it's not just a gamma problem.
Possibly worth noting: Older versions of wine (I think version 1.7.15 is an example) did this only at certain predictable points while playing Guild Wars 2. It happened when the launcher ran and when entering a new zone in the game. If I manually re-installed my color profile, it would stick until one of those transitions happened again, even if I switched to another virtual desktop in xfce and back to the game. In wine 1.7.45, it also kills my color profile whenever I switch back to the game's virtual desktop.