https://bugs.winehq.org/show_bug.cgi?id=43273
--- Comment #9 from Shmerl shtetldik@gmail.com --- (In reply to scix from comment #8)
It certainly looks to be AMD related. I have a save where it locks up with these symptoms almost immediately on a RX550 using AMDGPU + Mesa, but works perfectly on two nvidia cards (780 and 980ti).
Are you able to make an apitrace with this freeze? If you can, please post it in the related Mesa bug.